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Alice Gilman-Sachs Selected Research

Vacuolar Proton-Translocating ATPases (V-Type ATPase)

1/2018Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.
1/2016Selective inhibition of tumor cell associated Vacuolar-ATPase 'a2' isoform overcomes cisplatin resistance in ovarian cancer cells.
10/2015The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells.
1/2013An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase.
2/2011Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes.
3/2007The N-terminus domain of the a2 isoform of vacuolar ATPase can regulate interleukin-1beta production from mononuclear cells in co-culture with JEG-3 choriocarcinoma cells.

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Alice Gilman-Sachs Research Topics

Disease

9Neoplasms (Cancer)
10/2020 - 02/2011
6Inflammation (Inflammations)
01/2019 - 06/2007
6Spontaneous Abortion (Miscarriage)
06/2013 - 08/2002
4Infertility (Sterility)
01/2021 - 11/2012
4Neoplasm Metastasis (Metastasis)
01/2018 - 01/2013
4Breast Neoplasms (Breast Cancer)
01/2018 - 10/2015
3Infections
01/2018 - 04/2012
3Premature Obstetric Labor (Premature Labor)
01/2018 - 10/2015
2Ovarian Neoplasms (Ovarian Cancer)
10/2020 - 01/2016
2Premature Birth (Birth, Premature)
01/2018 - 01/2018
2Vitamin D Deficiency
11/2015 - 02/2014
1Neonatal Alloimmune Thrombocytopenia
01/2017
1Zika Virus Infection
01/2017
1Microcephaly
01/2017
1Genetic Predisposition to Disease (Genetic Predisposition)
02/2016
1Foreign Bodies (Foreign Body)
01/2016
1Carcinoma (Carcinomatosis)
01/2016
1Triple Negative Breast Neoplasms
10/2015
1Ischemia
09/2014
1Rheumatoid Arthritis
03/2014
1Pre-Eclampsia (Preeclampsia)
02/2014
1Bacterial Vaginosis
02/2014
1Gestational Diabetes (Gestational Diabetes Mellitus)
02/2014
1Virus Diseases (Viral Diseases)
12/2013
1Thrombosis (Thrombus)
06/2010
1Cytokine Release Syndrome
06/2010
1Infarction (Infarctions)
06/2010
1Fetal Death
10/2007
1Carcinogenesis
06/2007
1Choriocarcinoma
03/2007
1Pregnancy Complications
04/2006

Drug/Important Bio-Agent (IBA)

7Adenosine Triphosphatases (ATPase)IBA
10/2020 - 02/2011
7Protein Isoforms (Isoforms)IBA
10/2020 - 03/2007
7CytokinesIBA
01/2018 - 08/2002
6Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA
01/2018 - 03/2007
3LipopolysaccharidesIBA
01/2018 - 01/2016
3Notch ReceptorsIBA
11/2016 - 10/2015
3Interleukin-10 (Interleukin 10)IBA
02/2011 - 04/2006
2RNA (Ribonucleic Acid)IBA
01/2021 - 10/2020
2Toll-Like Receptors (Toll-Like Receptor)IBA
10/2020 - 06/2010
2Proton Pumps (Proton Pump)IBA
10/2020 - 09/2017
2Interleukin-22 (IL-22)IBA
01/2018 - 01/2018
2Proteins (Proteins, Gene)FDA Link
01/2018 - 06/2007
2AntibodiesIBA
01/2017 - 06/2010
2Jagged-1 ProteinIBA
01/2016 - 10/2015
2delta proteinIBA
01/2016 - 10/2015
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2016 - 10/2015
2LigandsIBA
01/2016 - 10/2015
2Vitamin DFDA LinkGeneric
11/2015 - 02/2014
2Poly I-CIBA
10/2015 - 12/2013
2Peptidoglycan (Murein)IBA
10/2015 - 12/2013
2AntigensIBA
04/2012 - 06/2007
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2007 - 04/2006
2Interleukin-1beta (Interleukin 1 beta)IBA
06/2007 - 03/2007
1DNA (Deoxyribonucleic Acid)IBA
01/2021
1Protons (Proton)IBA
10/2020
1Lactic Acid (Lactate)FDA LinkGeneric
10/2020
1Caspase 3 (Caspase-3)IBA
10/2020
1IodidesIBA
01/2020
1IodineIBA
01/2020
1GelatinasesIBA
01/2019
1Proteoglycans (Proteoglycan)IBA
01/2019
1Peptide Hydrolases (Proteases)FDA Link
01/2019
1Anti-Bacterial Agents (Antibiotics)IBA
01/2018
1Interleukin-6 (Interleukin 6)IBA
01/2018
1Therapeutic UsesIBA
09/2017
1Adenosine Triphosphate (ATP)IBA
09/2017
1Biological ProductsIBA
01/2017
1Immunoglobulin G (IgG)IBA
01/2017
1Intravenous Immunoglobulins (IVIG)FDA Link
01/2017
1Prednisone (Sone)FDA LinkGeneric
01/2017
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2017
1HLA-C Antigens (HLA-C)IBA
02/2016
1HLA Antigens (Human Leukocyte Antigens)IBA
01/2016
1Indicators and Reagents (Reagents)IBA
01/2016
1PlatinumIBA
01/2016
1Mifepristone (RU 486)FDA Link
01/2016
1Platinum Compounds (Compounds, Platinum)IBA
01/2016
1Pharmaceutical PreparationsIBA
01/2016
1Cisplatin (Platino)FDA LinkGeneric
01/2016
1Cytidine Monophosphate (CMP)IBA
10/2015
1Transcription Factors (Transcription Factor)IBA
10/2015
1Toll-Like Receptor AgonistsIBA
03/2015
1Receptor for Advanced Glycation End ProductsIBA
09/2014
1Antiphospholipid AntibodiesIBA
03/2014
1Immunoglobulin M (IgM)IBA
03/2014
1Heparin (Liquaemin)FDA LinkGeneric
06/2013
1MicroRNAs (MicroRNA)IBA
01/2012
1Biomarkers (Surrogate Marker)IBA
01/2012
1Peptides (Polypeptides)IBA
02/2011
1Phospholipids (Phosphatides)FDA LinkGeneric
06/2010
1Gonadotropin-Releasing Hormone (GnRH)FDA Link
06/2010
1Interleukin-1 (Interleukin 1)IBA
06/2007
1InterleukinsIBA
04/2006
1Immunoglobulins (Immunoglobulin)IBA
05/2005

Therapy/Procedure

2Therapeutics
10/2015 - 11/2012
1Treatment Delay
10/2020
1Immunotherapy
10/2020
1Subcutaneous Injections
01/2016
1Transplantation
01/2016